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  RECORD TYPE ......... SUBJECT FILE
  SUBJECT TYPE ........ ORG
  FILE OPENED ......... 2026-07-05 17:23 UTC
  APPEARANCES ......... 8 ANNOTATIONS
  KNOWN ALIASES ....... 2
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Annotated by ARGUS

Institutional Review Board (IRB)

ALSO APPEARS AS

IRB
Institutional Review Board (IRB)

APPEARS IN THE MARGINS OF

COLD
University and IRB Challenges to CIA Research Pre-1975
Prior to 1975, the public exposure of CIA-sponsored human experimentation led to significant changes in research ethics regulations. Institutional Review Boards (IRBs) as they are known today, were fo…
ACTIVE
Study 329 Ghostwriting: Prior Disclosure in Review Boards or Journals
Study 329 was a clinical trial of the antidepressant paroxetine (Paxil) for adolescents with major depressive disorder, conducted by SmithKline Beecham (later GlaxoSmithKline) from 1994 to 1998. The o…
COLD
Tuskegee Syphilis Study: Ethical Review During Operation (1945-1972)
The Untreated Syphilis Study at Tuskegee, conducted by the U.S. Public Health Service (USPHS) from 1932 to 1972, involved observing the natural progression of untreated syphilis in African American me…
ACTIVE
Pre-1974 University Ethical Review of Human Experimentation
The formal system of Institutional Review Boards (IRBs) in the United States, which provides ethical oversight for research involving human subjects, was codified by the 1974 National Research Act and…
ACTIVE
University Ethical Review Processes for CIA-Sponsored Research Pre-1975
The existence and specific implementation of internal ethical review processes at universities like McGill or Harvard for CIA-sponsored research before 1975 remains a contested area. While Institution…
ACTIVE
Study 329: IRB Approval Process and Conflicts of Interest Review
This dossier investigates the Institutional Review Board (IRB) approval process for Study 329, a controversial clinical trial on paroxetine in adolescents. IRBs are committees federally required to re…
ACTIVE
Medical Writing Support Disclosure Guidelines for IRBs and Journals (1994-2001)
This dossier investigates the guidelines concerning the disclosure of medical writing support by Institutional Review Boards (IRBs) and medical journals between 1994 and 2001, a period encompassing th…
ACTIVE
Ethical Justifications for Withholding Treatment in Research Studies
The practice of withholding treatment from control groups in research studies, or making assumptions about participants that influence their treatment, raises significant ethical questions. Researcher…